There's at least one C-46 operational that is on the airshow circuit. I met a fellow that flew in C-46s in the CBI flying over the "Hump" to China.
There's a cargo operation that flies out of Long Beach airport that operates DC-3s (they have at least three of them) to Santa Catalina Island. Apparently the only economical aircraft for the runway on the island.
The McDonald Douglass plant that built them, although gone now, was across the street, tested and flew the completed aircraft out of Long Beach airport, then known as Daugherty Field.