Hey Kab...wondering if you mean during a "Load"... This one is a bit easier, I too am now bound up with Arthritis... I use skateboard tape on some slides for grip, with no mag installed grip the slide and frame with opposing overhand grip and use your whole hand to open the slide. Lock the slide stop, insert full mag and then use the free hand to release the slide stop. I also have to use both hands now on pistols because the recoil hurts my thumb joint so much...