45 ACP should not go through. I would agree it’s been reamed out. 45 Colt seems like a likely candidate.
The moon clip issue is interesting. Mine drop right in.
Perhaps it’s had an entirely different cylinder dropped in that has a different spacing. That would explain the timing issue as well.

And by the way, I love those grips. Trench art type modifications to firearms are cool to me.
I’d gladly trade you the grips from my 1917 if you’re interested. Shoot me a PM if you are!