Winchester did produce one of their 50-110 cartridge loadings using a 22 rim fire blank cartridge in the nose of the lead bullet. It was thought that this might explode the bullet but in actual hunting did not really work.
Winchester's Model 1886 lever action rifle chambered the 50-110 plus a few Winchester Hi Wall single shot rifles.
My photo shows all the cartridges factory chambered in the model 1886 Winches carbine and rifle, (45-70 missing) the 50-110 is far right and has the 22 rim fire black cartridge in the bullet nose![]()